toggle menuMENU Can Monkeypox cases be asymptomatic and if this is possible, can they still spread the virus? Question:Can Monkeypox cases be asymptomatic and if this is possible, can they still spread the virus?Answer:Previous asymptomatic infection has been in those with low-level exposure to infected animals in Africa. Person to person transmission of monkeypox is rare and there is no animal reservoir of infection in the UK for this to occur.